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Search Result For 'postnatal development' , Result Number : 6

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Amal Soliman Soeilam
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
postnatal development
Dalia Abdelhameed Mandour
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Effect of Induced Hypoglycemia on Postnatal Development of The Adrenal Gland in Albino Rats
Dalia Abdelhameed Mandour
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Maternal exposure to the environmental pollutant "BDE-47" impairs the postnatal development of rat cerebellar cortex by modulating neuronal proliferation, synaptogenesis, NGF and BDNF pathways
Rasha Mohamed Sabry Hassan
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Prenatal and Postnatal Developmental Changes of Testes of Albino Rats
Nadya ebasiry Elsayed
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Background: The cerebellum is the second largest part of the mammalian brain. It is a key regulator of coordinated sensory and musculoskeletal actions. The cerebellar cortex has a striking morphology consisting of folia and fissures and a variety of cells which are morphologically and functionally different, so it’s considered as an ideal model to study the development of the central nervous system in the mammals. The Objectives: The aim of this work was to study the prenatal and postnatal development of the albino rat cerebellar cortex considering its structure and maturation. Material And Methods: 35 healthy, non-pregnant female and 18 male albino rats weighing (200-250 g) were obtained from the animal house, Faculty of Medicine, Zagazig University. After mating and pregnancy, the rat embryos and offsprings were divided into 3 groups and 6 subgroups; Group A (11th, 16th&20th fetal rats), Group B (7th, 14th &21st postnatal days rats) and Group C (3 months old rats). The fetal rats (11th and 16th) were fixed as whole, while the remaining prenatal, postnatal and adult rats were dissected to obtain cerebella, which were processed for light and electron microscopic examinations, morphometric and immunohistochemical studies. Results: Albino rats at prenatal day 11 (E11) showed formation of the neural tube from the ectodermal layer. Albino rats at prenatal day 16 (E16) showed a demarcated cerebellar anlage (rhombic lip ( at the dorsal part of the metencephalon. The cerebellar cortex at prenatal day 20 (E 20) showed appearance of the general architecture. From outwards to inwards, it consisted of external granular, molecular, Purkinje cell, internal granular layers. Thickness of the external granular layer was maximum at postnatal day 7 (D7) then gradually decreased with age till disappearance in adult age. The molecular layer showed a gradual increase in thickness with age till reaching its maximum size at adult stage. Purkinje cells at (E20) and (D7) were not arranged in a definite layer. It appeared as a single layer between the molecular and internal granular layer at D14, D21 and adult. The internal granular was consisted of scattered small granule cells at E20 and D7. At D14 the internal granular layer became well differentiated and distinguished from the white matter. Immunohistochemistry showed a negative reaction for glial fibrillary acidic protein (GFAP) at E11 and E16. The first positive reaction for GFAP appeared at E20 then gradually increased till adult group. Conclusion: The study concluded that the cerebellar cortex undergoes differentiation and maturation during late prenatal and early postnatal ages early postnatal ages till the third week of life, corresponding to nearly the seventh postnatal month in human. Therefore the development of the cerebellum is very critical and sensitive during these periods makes it susceptible to malformationPRENATAL AND POSTNATAL DEVELOPMENTAL CHANGES OF THE CEREBELLAR CORTEX IN ALBINO RATS
Nihal Ibrahim Ahmed Goda
- Faculty Research Area On Zu Site
- Faculty Research Area On Staff Site
Postnatal Development on Gastric Groove of Small Ruminants